DO NOT use Amaryl if
- are allergic to any ingredient in Amaryl
- have certain serious problems associated with diabetes (such as diabetic coma, diabetic ketoacidosis)
- have moderate to severe burns, or very high blood acid levels (acidosis)
- you are taking bosentan.
Contact your doctor or healthcare provider immediately if any of these apply to you.
Some medical conditions may interact with Amaryl. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breastfeeding
- if you are taking any prescription or non-prescription medicine, herbal preparation, or dietary supplement
- if you are allergic to medicines, foods or other substances
- if you have had a serious allergic reaction (eg, severe skin rash, hives, breathing difficulties, dizziness) to any other sulfonamide medicine, such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glipizide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide
- if you have a history of stroke or liver, kidney, thyroid, heart or blood vessel problems
- if you have stomach or intestinal problems (eg, stomach or intestinal blockage, stomach paralysis), drink alcohol, or have had a poor diet
- if you have type 1 diabetes, anemia, very poor health, high fever, a serious infection, severe diarrhoea, high levels of acid in your blood, or have suffered a serious injury
- if you have low levels of an enzyme called glucose 6-phosphate dehydrogenase (G6PD)
- if you have a history of certain hormonal problems (for example, adrenal or pituitary problems, syndrome of inappropriate secretion of antidiuretic hormone [SIADH]), or low blood sodium levels
- if you are going to undergo surgery.
Some medications can interact with Amaryl. Tell your doctor if you are taking any other medicines, especially any of the following
- Bosentan because liver problems may occur; the effectiveness of both drugs may decrease
- Beta-blockers (eg, propranolol) because it can increase the risk of low blood sugar. They can also hide certain signs of low blood sugar and make it harder to notice.
- Anticoagulants (eg, warfarin), azole antifungals (eg, miconazole, ketoconazole), chloramphenicol, clarithromycin, clofibrate, fenfluramine, insulin, metformin, monoamine oxidase inhibitors (eg, phenelzine), nonsteroidal anti-inflammatory drugs steroids (NSAIDs) (eg, ibuprofen), phenylbutazone, probenecid, quinolone antibiotics (eg, ciprofloxacin), salicylates (eg, aspirin), or sulfonamides (eg, sulfamethoxazole), either which can increase the risk of hypoglycemia
- Corticosteroids (eg, prednisone), decongestants (eg, pseudoephedrine), diazoxide, diuretics (eg, furosemide, hydrochlorothiazide), estrogens, hormonal contraceptives (eg, birth control pills), isoniazid, niacin, phenothiazines (eg, promethazine, phenytoin, rifamycins (eg, rifampicin), sympathomimetics (eg, albuterol, epinephrine, terbutaline), or thyroid supplements (eg, levothyroxine) because they may decrease the effectiveness of Amaryl, leading to an increase in blood sugar
- Gemfibrozil because it can raise or lower blood sugar.
This may not be a complete list of all interactions that may occur. Ask your doctor if Amaryl may interact with other medications you take. Check with your doctor before you start, stop, or change the dose of any medicine.
Important safety information:
- Amaryl may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medications. Use Amaryl with caution. Do not drive or perform other potentially unsafe tasks until you know how you react.
- Do not drink alcohol while taking Amaryl; can increase the risk of low blood sugar. Rarely, alcohol can interact with Amaryl and cause a serious reaction with symptoms such as flushing, nausea, vomiting, dizziness, or stomach pain. Discuss any questions or concerns you have with your doctor.
- To get the best results from Amaryl, it is important to follow a proper diet, exercise regularly, and regularly test your blood sugar. Follow the diet and exercise program prescribed by your doctor.
- It may be more difficult to control blood sugar during times of stress, such as fever, infection, injury, or surgery. Talk to your doctor about how to control your blood sugar level if any of these occur. Do not change the dose of your medication without consulting your doctor.
- Amaryl can cause low blood sugar. Low blood sugar levels can make you anxious, sweaty, weak, dizzy, sleepy, or faint. It can also make your heart beat faster; that your vision changes; give you a headache, chills, or tremors; Or make you hungrier. It is a good idea to carry a reliable source of glucose (for example, tablets or gel) to treat low blood sugar. If you don't have it, you should eat or drink a quick source of sugar, such as table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat at the same time every day and don't skip meals.
- The risk of low blood sugar may increase if you exercise vigorously or for a long time, drink alcohol, or skip meals.
- Amaryl can make you sunburn more easily. Avoid the sun, sunlamps, or tanning beds until you know how you react to Amaryl. Use sunscreen or wear protective clothing if you have to be outside for more than a short time.
- Tell your doctor or dentist that you take Amaryl before you receive any type of medical or dental care, emergency care, or surgery.
- Lab tests, including fasting blood glucose and hemoglobin, may be doneA1c, while using Amaryl. These tests may be used to monitor your condition or check for side effects. Be sure to keep all medical and laboratory appointments.
- Use Amaryl with caution in the elderly; they may be more sensitive to its effects, especially low blood sugar.
- Amaryl should be used with extreme caution in children; safety and efficacy in children have not been confirmed.
- Pregnancy and breast-feeding: Amaryl can cause harm to the fetus or newborn. If you become pregnant, see your doctor. You will need to discuss the benefits and risks of using Amaryl during pregnancy. It is not known if Amaryl is found in breast milk. Do not breast-feed while taking Amaryl.
When used for long periods of time, Amaryl may not work as well. If your blood sugar level has been under control and then becomes unmanageable, contact your doctor. Do not change the dose of your medicine without talking to your doctor.
Use Amaryl as directed in the leaflet