DO NOT use Indocin if:
- are allergic to any ingredient in Indocin
- have had a serious allergic reaction (such as severe skin rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (such as ibuprofen, celecoxib)
- have had or will recently have heart bypass surgery
- you are taking diflunisal, another NSAID (such as ibuprofen), or triamterene
- you are in the last 3 months of pregnancy
Contact your doctor or healthcare provider immediately if any of these apply to you.
Some medical conditions may interact with Indocin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breastfeeding
- if you are taking any prescription or non-prescription medicine, herbal preparation, or dietary supplement
- if you are allergic to medicines, foods or other substances
- if you have a history of kidney or liver disease, diabetes, or stomach or intestinal problems (for example, bleeding, perforation, ulcers, inflammation)
- if you have a history of swelling or fluid buildup, depression, mental or mood problems, seizures, Parkinson's disease, asthma, growths in the nose (nasal polyps) or inflammation of the mouth
- if you have high blood pressure, a blood disorder, bleeding or clotting problems, heart problems (for example, heart failure), or blood vessel disease, or if you are at risk of any of these conditions
- if you have health problems, dehydration or low fluid volume, low blood sodium levels or high blood potassium levels, if you drink alcohol or have a history of alcohol abuse.
Some medications may interact with Indocin. Tell your doctor if you are taking any other medicines, especially any of the following
- Anticoagulants (eg, warfarin), corticosteroids (eg, prednisone), diflunisal, heparin, other NSAIDs (eg, ibuprofen), salicylates (eg, aspirin), or selective reuptake inhibitors of serotonin (eg fluoxetine), as the risk of stomach bleeding may be increased.
- Potassium-sparing diuretics (eg, spironolactone, triamterene) because it may increase the risk of kidney problems or increased potassium levels in the blood
- Cyclophosphamide because low blood sodium levels may occur
- Probenecid because it may increase the risk of Indocin side effects
- Cyclosporine, digoxin, lithium, methotrexate, quinolones (eg, ciprofloxacin), or sulfonylureas (eg, glipizide) because the risk of their side effects may be increased with Indocin
- Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), angiotensin receptor antagonists (eg, losartan), beta-blockers (eg, propranolol), or diuretics (eg, diuretics). g., furosemide, hydrochlorothiazide) because their efficacy may be reduced by Indocin.
This may not be a complete list of all interactions that may occur. Ask your doctor if Indocin may interact with other medications you take. Check with your doctor before you start, stop, or change the dose of any medicine.
Important safety information:
- Indocin may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medications. Use Indocin with caution. Do not drive or perform other potentially unsafe tasks until you know how you react.
- Serious stomach ulcers or bleeding can occur with the use of Indocin. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Indocin with food does NOT reduce the risk of these effects. Contact your doctor or the emergency room right away if you have severe stomach or back pain; black, tarry stools; vomiting that looks like blood or coffee grounds; or unusual weight gain or swelling.
- DO NOT take more than the recommended dose or use it for longer than prescribed without consulting your doctor.
- Indocin is an NSAID. Before you start any new medicine, read the ingredients. If it also contains an NSAID (for example ibuprofen), consult your doctor. If you are not sure, ask your doctor or pharmacist.
- Do not take aspirin while you are using Indocin unless your doctor tells you to.
- Indocin may interfere with certain laboratory tests. Make sure your doctor and laboratory personnel know that you take Indocin.
- Laboratory tests, including kidney function, complete blood cell count, and blood pressure, may be done to monitor your progress or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Indocin with caution in the elderly; they may be more sensitive to its effects, including stomach bleeding, kidney problems, confusion, or mental changes.
- Indocin should be used with extreme caution in children under 15 years of age; safety and efficacy in these children have not been confirmed.
- Pregnancy and lactation: Indocin can harm the fetus. Do not use during the last 3 months of pregnancy. If you think you may be pregnant, see your doctor. You will need to discuss the benefits and risks of using Indocin during pregnancy. Indocin is found in breast milk. Do not breast-feed while you are taking Indocin.
Use Indocin as directed by your doctor! Check the medication label for exact dosage instructions.