DO NOT use Zoloft if
- are allergic to any ingredient in Zoloft
- are taking or have taken a monoamine oxidase inhibitor (MAOI) (for example phenelzine), selegiline or St. John's wort in the past 14 days
- you are taking a fenfluramine derivative (eg, dexfenfluramine), an H1 antagonist (eg, astemizole, terfenadine), nefazodone, pimozide, sibutramine, or thioridazine.
Contact your doctor or healthcare provider immediately if any of these apply to you.
Some medical conditions can interact with Zoloft. Tell your doctor or pharmacist if you have a medical condition, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breastfeeding
- if you are taking any prescription or non-prescription medicine, herbal preparation, or dietary supplement
- if you are allergic to medicines, foods or other substances
- if you or a family member have a history of bipolar disorder (manic-depressive), other mental or mood problems, suicidal thoughts or attempts, or alcohol or substance abuse
- if you have a history of seizures, heart problems, liver problems, stomach or intestinal bleeding, or metabolism problems
- if you are dehydrated, have low sodium levels in your blood, or drink alcohol
- if you are going to receive electroconvulsive therapy (ECT).
Some medicines can interact with Zoloft. Tell your doctor if you are taking any other medicines, especially any of the following
- Anorexiants (eg, phentermine), fenfluramine derivatives (eg, dexfenfluramine), linezolid, monoamine oxidase inhibitors (eg, phenelzine), metoclopramide, nefazodone, selegiline, 5-receptor agonists HT1 from serotonin (eg, sumatriptan), sibutramine, St. John's wort, or liner. John's wort, or trazodone because serious side effects can occur, such as a reaction that may include fever, muscle stiffness, changes in blood pressure, mental changes, confusion, irritability, agitation, delirium, and coma
- Anticoagulants (eg, warfarin), aspirin, or non-steroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because they may increase the risk of bleeding, including stomach bleeding
- Diuretics (eg, furosemide, hydrochlorothiazide) because they may increase the risk of high or low sodium levels in the blood
- Tramadol because it can increase the risk of seizures
- H1 antagonists (eg, astemizole, terfenadine) or phenothiazines (eg, chlorpromazine, thioridazine) because serious heart problems, including irregular heartbeat, can occur
- Carbamazepine or cyproheptadine because they can decrease the effectiveness of Zoloft
- Aripiprazole, clozapine, digoxin, flecainide, lithium, phenytoin, pimozide, propafenone, risperidone, tricyclic antidepressants (eg, amitriptyline), or valproate (eg, valproic acid) because the risk of their side effects may be increased with Zoloft .
This may not be a complete list of all the interactions that can occur. Ask your doctor if Zoloft can interact with other medicines that you take. Check with your doctor before starting, stopping, or changing the dose of any medicine.